As a result, four genes were selected: IRX2, LMO3, ANXA10, and TFF2. Two genes (IRX2, LMO3) were up-regulated, and the remaining two (ANXA10, TFF2) were down-regulated by the expression of mutant LRRK2. Taken together, our results suggested that these genes might be potential factors that could possibly emerge in PD pathology. Here, TFF2 is linked to Parkinson disease.