IRX2 and Parkinson disease: As a result, four genes were selected: IRX2, LMO3, ANXA10, and TFF2. Two genes (IRX2, LMO3) were up-regulated, and the remaining two (ANXA10, TFF2) were down-regulated by the expression of mutant LRRK2. Taken together, our results suggested that these genes might be potential factors that could possibly emerge in PD pathology.