For instance,nuclear factor 1B (NF1B)—a transcription factor required for the regulation of celldifferentiation—functions as both a tumor suppressor (non-small cell lung cancer andosteosarcoma) as well as an oncogene (small cell lung cancer and melanoma) (Becker-Santoset al., 2017). Here, NFIB is linked to non-small cell lung carcinoma.