In fact, the interactome of the Menkes ATPase ATP7A and the proteome of ATP7A null cells are enriched in gene products involved in neurodegenerative and neurodevelopmental diseases, suggesting a larger complexity to the pathogenesis mechanisms in Menkes neurological disease (Comstra et al., 2017, Hartwig et al., 2019, Zlatic et al., 2018). This evidence concerns the gene ATP7A and nervous system disorder.