Of those who had inflammatory nondemyelinating CNS events, exposure to TNF inhibitors occurred in 7 of 8 patients with neurosarcoidosis (88%), 3 of 4 patients with meningoencephalitis (75%), 9 of 15 patients with lepto-pachymeningitis (60%), 3 of 7 patients with encephalitis (43%), and 3 of 8 patients with aseptic meningitis (38%) (Table 2). The gene discussed is TNF; the disease is neurosarcoidosis.