We tested seven compounds that have similar chemical structures to 4PBA for their effect on the global expression of missense mutant bestrophin 1 proteins associated with either BVMD (p.L234V and p.N296S) or ARB (p.M325T) in stably transfected MDCKII cells (Supplementary Fig. S1A). The gene discussed is BEST1; the disease is Best vitelliform macular dystrophy.