Using data from GEPIA, it was noted that ccRCC patients exhibiting genomic alteration in TIMP1 demonstrated a reduction in overall and disease-free survival (P=6.8x10-7 for overall survival and P=3.7 x10-5 for disease-free survival) (Figure 3A, 3B). This evidence concerns the gene TIMP1 and nonpapillary renal cell carcinoma.