MYOM2 and infection: Because the NNSVs M proteins can avoid the inhibition of viral transcriptase activity early in infection and mediate the association of the nucleocapsid with the nascent viral envelope later in infection, thus we concluded that the dominant nuclear accumulation of NDV M protein might ensure that viral RNA synthesis and transcription in the cytoplasm proceeded smoothly until a certain level of viral RNA and protein expression was synthesized, at which point the M protein entered the cytoplasm and plasma membrane to achieve virus assembly and budding.