FANCL and cancer: Here, we characterize FANCL URD hydrophobic patch mutations that have previously been shown to impair substrate binding [14] (Figure 2A), the FA mutation R221C [19], and mutants found from cancer cell sequencing studies collated in cBioPortal (Figure 2B) [10,11]: F110S [20], I136V [12], L149V [21], L154S, A192G [22], E215Q [23], E217K [24], R221W [25], T224K, M247V, F252L, N270K, V287G [25], E289Q [26].