TDRD7 and cataract: Indeed, TDRD7 has been shown to be a component of ribonucleoprotein complexes and RNA granules in differentiating lens and sperm cells, and interestingly, Tdrd7 deficiency in mice causes two prominent fully penetrant defects involving both of these distinct cell types, namely, cataracts and male-specific sterility resulting from azoospermia (17, 23, 32).