CELF1 and cataract: Specifically, the finding that eye/lens defects or cataracts can be caused by functional compromise of post-transcriptional regulatory proteins such as TDRD7, CELF1, RBM24 or CARPIN2 was unanticipated since the majority of prior known cataract-causing mutations disrupted lens structural proteins or transcription factors (2, 12, 14, 16, 20, 55–57).