To address this deficit and gain insight into the molecular and cellular basis of the cataract pathology that arises from TDRD7 deficiency, in the present study, we have applied diverse approaches at the phenotypic, cellular, molecular and system levels to investigate the cataract defect in Tdrd7−/− mice, which closely phenocopies congenital cataract in humans. This evidence concerns the gene TDRD7 and cataract.