Oral treatment of age-related hepatic steatosis either with BDS (450 mg/kg), PDS (30 mg/kg), CDS (30 mg/kg) or ZH (250 μg/kg) regulated the serum levels of adiponectin, Apo B100, and insulin, whereas adiponectin levels were elevated by about 2.6, 2.3, 2.4, and 3.1 folds, respectively. Here, INS is linked to fatty liver disease.