Treatment of age-related hepatic steatosis with D. salina microalgae and its isolated zeaxanthin in senescence rats showed a counteracting effect on the hepatic levels of IL-6 and its modulator NF-κB. On the other hand, adiponectin levels that have been elevated in the treated groups are negatively associated with mediators of inflammation, viz, IL-6, which are mainly produced from Kupffer cells and hepatic stellate cells and partly from inflamed hepatocytes. The gene discussed is NFKB1; the disease is fatty liver disease.