Both univariate and multivariate Cox analyses showed that the expressions of INPP5K (hazard ratio = 1.5, 95% confidence interval: 1.06-2.13, P = 0.023), residual tumor (hazard ratio = 1.42, 95% confidence interval: 1.11-1.82, P = 0.005), and T classification (hazard ratio = 1.81, 95% confidence interval: 1.44-2.29, P ≤ 0.001; Table 3) were independent risk factors for poor overall survival in liver cancer patients. The gene discussed is INPP5K; the disease is neoplasm.