SMAD3 and colon adenocarcinoma: Kaplan–Meier analysis using GEPIA revealed that COAD patients with high expression levels of CDKN2A had poorer overall survival times than those with low expression levels (P < 0.05; Figure 10(a)); there was no statistically significant effect on OS associated with the expression of IGF1R, MDM2, SMAD3, SLC2A1, GRM5, PLCB4, FGFR1, UBE2V2, or TNFRSF10B (P > 0.05; Figures 10(b)–10(i)).