KIR3DL1 and myelodysplastic syndrome: Because individual HLA allotypes belonging to the HLA-Bw4 group recognize distinct peptide motifs, it is unlikely that common peptide recognition explains the protection conferred by HLA-Bw4, which suggest that as the ligand for KIR3DL1, HLA-Bw4 protection against MDS probably has to do with NK cell-mediated immune response [22].