Furthermore, it has been shown to suppress overexpression of ICAM-1, TNF-α, IL-1 β, and IL-6 in an acute pancreatitis rat model and a transplanted small bowel pig model (Chen, Chen & Tseng, 2009a; Chen, Chen & Tseng, 2009b; Chen et al., 2009; Wang, Lemos & Iadecola, 2004). The gene discussed is TNF; the disease is acute pancreatitis.