And it was also upregulated in CRC, gliomas, renal cell carcinoma (RCC) tissue and indicated poor prognosis of patients with CRC (Yang et al., 2018) and RCC (He et al., 2017), it bound miR-215 and vimentin in CRC, negatively regulating miR-342-3p in gliomas to promote proliferation and invasion (Zhang et al., 2017). The gene discussed is VIM; the disease is central nervous system cancer.