YWHAZ and osteosarcoma: LINC00858 expression was observed to be up-regulated in colorectal cancer (CRC), osteosarcoma and non-small cell lung cancer (NSCLC) tissues, and associated with poor prognosis, which is in line with our hypothesis, and it exerted its functional effect through the miR-22-3p/YWHAZ axis in CRC (Sha et al., 2019).