Through αvβ5/Akt/NF-κB signaling pathway, Cyr61 can stimulate synovial cells to secrete high concentrations of IL-6, which promotes the differentiation and proliferation of local Th0 cells into Th17 and the production of IL-17, forming a new inflammatory pathway for rheumatoid arthritis (RA) local arthropathy [12]. Here, CCN1 is linked to rheumatoid arthritis.