Immunohistochemistry showed that values of Bcl-2 and Akt PEI of myocardial tissue of model group significantly decreased, while values of Bax PEI significantly increased (P < 0.01), showing significant myocardial damage, which also indicates that the myocardial ischemia modeling method used in this article is successful. The gene discussed is BCL2; the disease is myocardial ischemia.