In our study, more interestingly, we performed univariate, LASSO, and multivariate Cox regression analyses to develop a prognostic related risk signature with two m6A RNA methylation regulators, METTL3 and METTL14, which divided the ccRCC patients into low- and high-risk groups. The gene discussed is METTL14; the disease is nonpapillary renal cell carcinoma.