A study by Gröbner et al. (2018) reported that 5% of a total of 42 cases of MBSHH in their cohort were associated with germline PTEN variants, suggesting, in addition, that pediatric tumors demonstrate a rate of new mutations that is 14 times lower than that observed in adult cancer, suffering, instead, from a higher incidence of germline mutations (7.6%). Here, PTEN is linked to cancer.