PTEN and Macrocephaly: While macrocephaly (+3.3 to 5.5 SD in males and +2.9 to 4.1 SD in females) is a known diagnostic feature of germline PTEN variants (Plamper, Gohlke, Schreiner, & Woelfe, 2019; Tan, Mankad, Goncalves, Talenti, & Alexia, 2018), no imaging recommendations exist for follow‐up in macrocephaly (i.e., head circumference higher than 2 SD above the mean), particularly for patients with a positive family history of macrocephaly and no risk factors or neurological symptoms (Sampson, Berg, Huber, & Olgun, 2019; Tan et al., 2018).