Treatment with TNF resulted in the formation of the TNF receptor signalling complex‐I (TNFR‐SC, also referred to as complex‐I) in the human fibrosarcoma cell line HT1080, as evidenced by the recruitment of bona fide TNFR‐SC components such as RIPK1, SHARPIN and TRADD (Fig EV2A) (Micheau & Tschopp, 2003). Here, TNFRSF1A is linked to fibrosarcoma.