Importantly, this rat model closely resembles the clinical scenario seen in many patients with advanced limb sarcomas after treatment with standard ILP‐TNF/Mel, where an initial local response is followed by local disease progression that may occur before the development of metastatic disease (Pencavel et al, 2015; Wilkinson et al, 2016; Smith et al, 2019). Here, TNF is linked to sarcoma.