I‐1, who was the carrier of both HKαα/‐α3.7 and β41‐42/βN, showed a typical β‐thalassemia trait characterized by increased HbA2 (6.4%) and microcytic hypochromic anemia with mild reduction in mean cell volume (MCV), mean cell hemoglobin (MCH), and mean corpuscular hemoglobin concentration (MCHC). The gene discussed is HBA2; the disease is anemia (phenotype).