CD8A and colorectal carcinoma: Intraepithelial CD8+ lymphocytes have been linked to favourable prognosis in CRC and are associated with antitumour immunity.34 Furthermore, it has been postulated that intraepithelial CD8+ lymphocytes play an important role in the suppression of micrometastasis and hence are associated with a decrease in distant metastasis.34 The higher expression of intraepithelial CD8+ lymphocytes in patients with dHGP therefore corroborates the recent findings that patients with non-dHGP are at higher risk for extrahepatic and multi-organ recurrences following first surgical treatment of CRLM.35