NUAK1 and breast cancer: In the C-terminal catalytic domain of NUAK1 there is a site for liver kinase B1 (LKB1) phosphorylation and activation.65 After the activation, NUAK1 is able to control cell motility through the assembly and disassembly of cytoskeletal proteins.66 Importantly, LKB1 is a tumour suppressor kinase and its loss promotes breast cancer metastasis and invasion.67,68