RNF8 and cancer: Additionally, miR-622 suppresses migration and invasion of colorectal cancer cells by targeting K-RAS18 and DYRK2.19 In lung cancer, miR-622 is able to inhibit cancer metastasis by suppressing HIF-1α.20 In glioma miR-622 targets YAP11 and in breast cancer targets RNF8.21 Finally, a recent paper reported that in renal cell carcinoma, miR-622 suppressed cancer progression by targeting CCL18.22