Kaposi’s sarcoma herpes virus (KSHV) is an oncogenic virus belonging to gammaherpesvirus family associated with several human malignancies such as Kaposi’s sarcoma, primary effusion lymphoma (PEL) and Castleman’s disease.1 KSHV encodes for many proteins homologue to human proteins that favour oncogenesis, counteract apoptosis and subvert immune response such as viral G-protein-coupled receptors (GPCRs), viral Cellular FLICE-inhibitory protein (FLIP) and viral interleukin 6 (IL-6). This evidence concerns the gene IL6 and Castleman disease.