NTRK1 and colorectal carcinoma: In November 2018, the FDA approved the specific TRK inhibitor larotrectinib for the treatment of tumours with NTRK1/2/3 fusions, with an overall response rate of 75% (including two of three patients with CRC) and a median duration of response and PFS not attained after a median follow-up of 9.4 months (PFS at 1 year: 55%) [39].