Haapasalo et al. [20] reported that grade II–IV astrocytomas (diffuse astrocytomas) showed more intense staining by TrxR and Trx than grade I astrocytomas, and within diffuse astrocytomas, TrxR and Trx showed significantly increasing expression with the malignancy grade. This evidence concerns the gene TXN and astrocytoma (excluding glioblastoma).