Here, we observed that Pao extract downregulates the expression levels of CXCL5, CXCL6, CXCL12, HAS2, MMP13 and TNC in BPH-1 and WPMY-1 cells, thus indicating that Pao extract attenuates the inflammation and ECM-remodeling via inhibition of NFκB signaling in BPH. The gene discussed is CXCL6; the disease is benign prostatic hyperplasia.