IFI16 and infection: PRR sensing by IFI16 during HSV-1 ΔICP0 infection correlates with IFI16 forming nuclear filaments on vDNA in association with PML following the saturation of PML-NBs under high genome loads (Alandijany et al., 2018; Cuchet-Lourenco et al., 2013; Merkl and Knipe, 2019).