PML-NBs are highly dynamic nuclear substructures composed of more than 70 proteins that respond to a variety of stimuli, including heat shock, cytokine signalling, and virus infection (Lang et al., 2010; Van Damme et al., 2010; Hoischen et al., 2018; Lang et al., 2019; Bernardi and Pandolfi, 2007; Maul et al., 1995). The gene discussed is PML; the disease is viral infectious disease.