NOTCH1 and acute lymphoblastic leukemia: Multiple signaling pathways involved in T-ALL can be regulated through downstream target genes once the Notch1 signaling pathway is activated: 1) the expression of target gene MYC is regulated to activate the anabolism-related Notch1-MYC signaling pathway, promote the expression of anabolism-related genes, and further facilitate cell proliferation and metabolism [30,31].