MAML1 and acute lymphoblastic leukemia: Similarly, in studies on MAML1 that acts on the transcriptional complex at the end of the pathway, and indicating that MAML1 may be a potential therapeutic target for T-ALL, the knockdown of the MAML1 gene has been found to remarkably suppress the proliferation of T-ALL cell lines and induce the G0/G1 cell cycle arrest and apoptosis [99].