Studies have also found that a polypeptide, SAHML1, is able to penetrate cells and target the formation of the ICN1-CSL-MAML1 transcriptional complex at the end of the Notch1 signaling pathway, thereby effectively blocking the Notch1 signaling pathway, and its potent antileukemia effect has been confirmed in the mouse model of T-ALL caused by NOTCH1 gene mutation [98]. Here, NOTCH1 is linked to T-cell acute lymphoblastic leukemia.