The present study suggests that in seropositive pSS, anti‐SSA and anti‐SSB autoantibodies cause dysfunction in nodal and internodal region of the axon and small nerve fibers; Meanwhile, in seronegative patients, the autoreactive antibodies probably exert its neuropathogenic effects mainly by affecting the small nerve fibers instead of the axon. The gene discussed is SSB; the disease is peeling skin syndrome.