These reports mention angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARBs), which are commonly used drugs to treat patients with hypertension, heart failure, or kidney complications in diabetes mellitus, as well as ibuprofen, which is an over-the-counter drug prescribed or used to treat arthritis and rheumatic diseases among other indications. This evidence concerns the gene ACE and hypertensive disorder.