ACE2 and myocardial infarction: In animal models of arterial hypertension, myocardial infarction, pressure overload, or diabetes mellitus, cardiac ACE2 was downregulated compared with healthy control animals (Ocaranza et al. 2006; Tikellis et al. 2006; Qiao et al. 2015; Wang et al. 2016; Zhao et al. 2019).