C2 and age-related macular degeneration: Another noteworthy finding was bin 6.IV (chr6: 31,878,006–31,878,721 bp) with five rare variants in the C2 gene (MAF ≤ 0.05) was found to be significantly associated with AMD with p value of 3.78 × 10−80, p′ value of 1.23 × 10−70, and OR = 0.53 [0.50, 0.57] (Fig. S19).