We also noticed transcriptional differences between B-ALL subtypes (e.g. RAG1 over expressed in ETV6-RUNX1 samples) and individuals (e.g. TCL1B over expressed in samples ETV6.RUNX1.3/ETV6.RUNX1.4 and CD1E over expressed in sample PRE-T.1). The gene discussed is RUNX1; the disease is precursor B-cell acute lymphoblastic leukemia.