Hence, IL-15 mediates NKG2D expression on CD8αα T-IEL following poly(I:C) treatment in vivo,58 infection with Entamoeba moshkovskii triggers IFNγ production which is required for NKG2D expression on TCRαβ CD8αα T-IEL,59 and increased IL-1β production regulates γδ T-IEL NKG2D expression following Salmonella typhimurium infection in TLR9−/− mice.60 Of note, in addition to upregulating NKG2D expression, these cytokines also facilitated NKG2D ligand expression on epithelial cells.59,60. Here, KLRK1 is linked to infection.