In humans, a population of colonic CD8αβ+ γδ T-IEL that express Vδ1 constitutively express high levels of NKp46,120 a member of the natural cytotoxicity receptors family (NCR), normally found on NK cells.121 In vitro cytotoxic assays against K562 and colon adenocarcinoma cell lines showed that NKp46 expression on Vδ1 T-IEL is associated with high cytotoxic potential and IFNγ production. This evidence concerns the gene IFNG and colon adenocarcinoma.