In humans, NKG2D is found at the surface of both resting and activated CD8+ T cells while murine T cells only express NKG2D when activated.56 Consistent with this, NKG2D is found at the surface of all murine DETC57 and human intestinal T-IEL, albeit at low levels.55 Although NKG2D is not expressed at the surface of murine intestinal T-IEL in normal conditions, cytokine-dependent NKG2D upregulation has been observed during infections. The gene discussed is KLRK1; the disease is infection.