It has also been reported that TL/CD8αα interaction modulates T-IEL production of cytokines such as IL-2 and IFNγ and curbs T-IEL cytotoxicity.85,91 Yet TL deficiency does not lead to spontaneous colitis/IBD nor does it affect the outcome of chemically-induced colitis in mice. This evidence concerns the gene IFNG and colitis.