In consistent with the reduction in tumor growth, there was also a significant reduction in the proliferation marker, Ki-67 (Fig. 6i, j) and an increase in the expression of an apoptosis marker, Cleaved Caspase-3 (Fig. 6k, l) in combination-treated group as compared to LOX inhibition or doxorubicin treatment alone. This evidence concerns the gene LOX and neoplasm.