To test the effect of FAK or Src inhibition on doxorubicin response in vivo, we combined specific inhibitors of FAK (PF-562271) or Src (Saracatinib) with doxorubicin and observed a significant decrease in tumor growth (Fig. 4p–s) and tumor weight (Supplementary Fig. 10e, f) in combination-treated tumors, validating the key roles of FAK and Src in doxorubicin resistance. The gene discussed is PTK2; the disease is neoplasm.