In the univariate analysis, tumor size (P < 0.001), pathological TNM stage (P < 0.001), AJCC grade (P < 0.001), pre-NCRT carcinoembryonic antigen (CEA) level (P = 0.025), pre-NCRT CA19–9 level (P < 0.001), anemia (P = 0.007), NLR level (P < 0.001), SII level (P = 0.001), MLR level (P = 0.001), PLR level (P = 0.004), and tumor differentiation (P < 0.001) were independently associated with OS in LARC patients following NCRT and TME (Table 1). The gene discussed is CEACAM5; the disease is anemia (phenotype).