To determine the roles of MEGF11 in tumour behaviour, we knocked down MEGF11 in two TNBC cell lines, MDA-MB-231 and MDA-MB-468, and found that there was a significant decrease in the cell proliferation rates of both types of ∆MEGF11 cells; the doubling times of the wild type MDA-MB-231 and MDA-MB-468 cells were 1.57 d and 2.54 d, respectively, and those of the ∆MEGF11 MDA-MB-231 and ∆MEGF11 MDA-MB-468 lines were 4.34 d and 3.25 d, respectively (Supplementary Information 3). Here, MEGF11 is linked to neoplasm.