Assessment of known UM driver genes revealed an oncogenic driver mutation in 102 of 103 tumours: 51 in GNAQ (48 p.Q209P/L, two p.R183Q, one p.G48L), 46 in GNA11 (44 p.Q209L/P, two p.R183C), five in PLCB4 (three p.D630Y, two p.D630N) and two in CYSLTR2 (p.L129Q). This evidence concerns the gene PLCB4 and neoplasm.