A hotspot mutation p.R175H (n = 1216 in IARC TP53 database) was observed in a hypermutated metastatic UM with deficient MBD433 and another hotspot mutation p.M237I (n = 196 in IARC TP53 database) was observed in a UM in a pan-cancer study of metastatic tumours17. This evidence concerns the gene TP53 and cancer.