Yet, combined transfection of siRNAs directed towards all three different target ISGs (IFIH1, TMEM2, and IFITM3) induced a significant increase in ZIKV replication in pDCs, consistent with an important role of these ISG for restriction of ZIKV infection in pDC (Fig. 3f and Supplementary Fig. 1d). Here, IFIH1 is linked to Zika virus infectious disease.