IFNA1 and Zika virus infectious disease: We observed that during in vitro culture, experimental depletion of pDCs strongly enhanced the susceptibility of PBMCs to ZIKV infection, while profoundly reducing IFNA mRNA levels in response to ZIKV infection, emphasizing the critical role of pDC-dependent type I IFN responses for effective human immune defense against ZIKV (Fig. 6a, b and Supplementary Fig. 5b).