Moreover, the lower frequency of IgD and IgM transcripts and the higher frequency of IgG, IgA, and IgE transcripts in B cells of ZIKV-infected patients compared to uninfected donors (Supplementary Fig. 4a) supports the idea of a higher maturation and differentiation of B cells following ZIKV infection. The gene discussed is IGHE; the disease is Zika virus infectious disease.