IFITM3 and Zika virus infectious disease: Yet, combined transfection of siRNAs directed towards all three different target ISGs (IFIH1, TMEM2, and IFITM3) induced a significant increase in ZIKV replication in pDCs, consistent with an important role of these ISG for restriction of ZIKV infection in pDC (Fig. 3f and Supplementary Fig. 1d).