Yet, combined transfection of siRNAs directed towards all three different target ISGs (IFIH1, TMEM2, and IFITM3) induced a significant increase in ZIKV replication in pDCs, consistent with an important role of these ISG for restriction of ZIKV infection in pDC (Fig. 3f and Supplementary Fig. 1d). The gene discussed is CEMIP2; the disease is Zika virus infectious disease.