In the present work, we have conducted a parallel, unbiased transcriptional profiling analysis of mDCs, plasmacytoid DCs (pDCs), natural killer (NK) cells, B cells, CD4 T cells, and CD8 T cells from three individuals who were diagnosed with ZIKV infection during the 2016–2017 ZIKV disease outbreak in the Caribbean. This evidence concerns the gene CD4 and Zika virus infectious disease.