To gain systemic insight into the immune response caused by ZIKV infection in humans, we conducted RNA sequencing (RNA-Seq)-based transcriptional profiling experiments to characterize gene expression changes in seven immune cell populations (CD4 T cells, CD8 T cells, B cells, NK cells, monocytes, mDCs, and pDCs) from the peripheral blood of three study individuals with acute ZIKV infection; cells from three gender- and age-matched healthy individuals were treated identically and were used as reference samples. Here, CD4 is linked to Zika virus infectious disease.