In accordance, intravenous administration of Elesclomol for nine days reduced local tumor growth of TC-32 EwS xenografts in vivo (Fig. 4h), which was accompanied by induction of apoptosis and cell death as indicated by increased numbers of cells positive for cleaved caspase 3 (Fig. 4i), and more necrotic tumor area (Fig. 4j). The gene discussed is CASP3; the disease is neoplasm.