We agreed that knockdown of COX6B2 resulted in downregulated mitochondrial respiration; however, a boosted Warburg effect was not observed in COX6B2 KD cells, while neither cell nor tumor growth were altered by the repression of COX6B2 (Fig. 2a–e), which was further confirmed by the fact that extracellular acidification rate was not altered in 8988 cells with KD of COX6B2 (Fig. S7). Here, COX6B2 is linked to neoplasm.