COX6B2 and cancer: Notably, cells with repressed OXPHOS function due to KD of COX6B2 appeared to exert little effect on the glycolytic process, and cancer cell growth both in vivo and in vitro, indicating that Warburg effect was not activated in PDAC cells with KD of COX6B2. Alternatively, COX6B2 might support the TCA outputs of amino acids for biosynthesis, which are essential for cell proliferation and cycle progression27.