CD8A and type 1 diabetes mellitus: Whereas our cohort of T1D patients considered as a group had significantly more CD8+ T cells reactive to pancreatic islet autoantigens than matched HD (Fig. 5A, left panel), this parameter could not distinguish most patients, either from one another or from healthy controls (Supplemental Fig. 6A, and Fig. 5A, left panel) [16,25].