To determine whether TDS cell representation might be informative vis-a-vis ongoing infection, we applied the strategy shown in Supplemental Fig. 4C to examine HLA-A*02-restricted CD8+ T cells reactive to a single immunodominant Epstein Barr virus peptide (EBV BMLF1280-288), as detected via multimeric peptide-HLA (pHLA) tetramers (“EBV tetr”) [22]. Here, CD8A is linked to infection.