To better understand the functional implications of TDS assay in T1D patients, Nanostring gene expression analyses were undertaken for islet tetr+ CD8+ T cells purified from: two T1D patients bearing highly proliferative [TDShi] cells (see above), two donors bearing TDSlo cells; two TDS− donors; and 3 HDs. This evidence concerns the gene CD8A and type 1 diabetes mellitus.