The effect of Pan-HER has been investigated in a number of cell lines and xenografts representing a diverse number of cancer types including head and neck, lung [16, 17], HER2+ breast [18], and other malignancies shown to have a dependency on one or more of the targets, i.e., EGFR, HER2, or HER3 [4]. The gene discussed is EGFR; the disease is cancer.