INS and diabetes mellitus: Of these patients, 265 (62.8%)were men, 128(30.3%) current consumed alcohol, 149(35.3%) had a history of current smoking, 414 (98.4%) had type 2 diabetes, and 230 (54.5%)used insulin; the mean duration of diabetes was 9.7 ± 7.7 years, and the mean duration of DFU was 57.6 ± 78.6 days (Table 1).