MSH2 and hereditary breast ovarian cancer syndrome: Examples of clinically actionable conditions included hereditary breast and ovarian cancer (HBOC) syndrome (BRCA1/2), Lynch syndrome (MLH1, MSH2, MSH6 and PMS2), and familial hypercholesterolemia (LDLR, APOB and PCSK9), all of which have Centers for Disease Control and Prevention (CDC) tier-one level of evidence for reducing morbidity and mortality in certain indications [12].