Finally, 35 different articles [26, 30–57, 67–71] were selected, including 38 studies about HTRA1 gene rs11200638 polymorphism and AMD risk (Table 1) and 27 case-control studies about HTRA1 gene rs11200638 polymorphism and wet or dry AMD risk (Table 2). Here, HTRA1 is linked to age-related macular degeneration.