Hence, in pancreatic cancers, the reduction of LINC00261 may trigger the loss of E-cadherin-dependent cell–cell contacts, thereby enhancing the invasive capabilities of pancreatic cancer cells, resulting in a more aggressive subtype of PDAC and a poor survival of patients whose tumors present a low LINC00261 expression. This evidence concerns the gene CDH1 and familial pancreatic carcinoma.