Recently, it was shown that activation of chromatin regulator EZH2, which is the catalytic subunit of the PRC2 complex for histone H3 lysine 27 tri-methylation (H3K27me3) potentially silences IGFBP4, which alleviate Akt signaling that leads to aberrant epigenetic reprograming during hepatocellular carcinoma (HCC) progression. The gene discussed is IGFBP4; the disease is hepatocellular carcinoma.