We observed a clustering of the novel gene fusions VTI1A-TCF7L2 and SND1-TMEM178B along with the commonly reported FGFR3-TACC3 and AGK-BRAF fusions in the GBM tissue of patients P1-P3, who were fusion-positive by the MGH Solid Fusion Assay. The gene discussed is TCF7L2; the disease is glioblastoma.