Congenital limb malformations, ectodermal dysplasias, and facial clefts are the main characteristics of human patients with TP63 mutations such as ectodermal dysplasia and cleft lip/palate (EEC) syndrome and acro-dermato-ungual-lacrimal-tooth (ADULT) syndrome [94]. The gene discussed is TP63; the disease is ectodermal dysplasia syndrome.